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Article

LRRK2 promotes the activation of NLRC4 inflammasome during <i>Salmonella</i> Typhimurium infection

18 Aug 2017

Abstract excerpt

Although genetic polymorphisms in the LRRK2 gene are associated with a variety of diseases, the physiological function of LRRK2 remains poorly understood. In this study, we report a crucial role for LRRK2 in the activation of the NLRC4 inflammasome during host defense against Salmonella enteric serovar Typhimurium infection. LRRK2 deficiency reduced caspase-1 activation and IL-1β secretion in response to NLRC4...

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PMID: 28821568
DOI: 10.1084/jem.20170014

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