Article
Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain.
Molecular neurodegeneration - 10 Jan 2022
Xu Enquan, Boddu Ravindra, Abdelmotilib Hisham A, Sokratian Arpine, Kelly Kaela, Liu Zhiyong, Bryant Nicole, Chandra Sidhanth, Carlisle Samantha M, Lefkowitz Elliot J, Harms Ashley S, Benveniste Etty N, Yacoubian Talene A, Volpicelli-Daley Laura A, Standaert David G, West Andrew B
Abstract excerpt
BACKGROUND: Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson's disease (PD). Aggregated α-synuclein pathologically defines PD. Recent studies identified elevated LRRK2 expression in pro-inflammatory CD16+ monocytes in idiopathic PD, as well as increased phosphorylation of the LRRK2 kinase substrate Rab10 in monocytes in some LRRK2 mutation carriers. Brain-engrafting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.