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Article

The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease.

Biochemical Society transactions - 26 Apr 2023

Strader Samuel, West Andrew B

Abstract excerpt

The accumulation of aggregated α-synuclein in susceptible neurons in the brain, together with robust activation of nearby myeloid cells, are pathological hallmarks of Parkinson's disease (PD). While microglia represent the dominant type of myeloid cell in the brain, recent genetic and whole-transcriptomic studies have implicated another type of myeloid cell, bone-marrow derived monocytes, in disease risk and...

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PMID: 37013975
DOI: 10.1042/BST20201091
PMCID: PMC11110874

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