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Effect of LRRK2 protein and activity on stimulated cytokines in human monocytes and macrophages

28 Mar 2022

Abstract excerpt

Leucine-rich-repeat kinase 2 (LRRK2), a potential therapeutic target for the treatment of Parkinson's disease (PD), is highly expressed in monocytes and macrophages and may play a role in the regulation of inflammatory pathways. To determine how LRRK2 protein levels and/or its activity modulate inflammatory cytokine/chemokine levels in human immune cells, isogenic human induced pluripotent stem cells (iPSC) with...

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PMID: 35347144
DOI: 10.1038/s41531-022-00297-9

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