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Dopamine D2 receptor upregulation in dorsal striatum in the <i>LRRK2</i> -R1441C rat model of early Parkinson’s disease revealed by <i>in vivo</i> PET imaging

2023-08-13

Abstract excerpt

LRRK2 mutations are the most common cause of dominantly inherited Parkinson’s disease (PD). Here, we conducted PET imaging in aged transgenic rats carrying human pathogenic LRRK2 R1441C or G2019S mutations with [ 18 F]FDOPA and dopamine D2/3 receptor ligand [ 18 F]fallypride. We interrogate presynaptic integrity and postsynaptic dopamine receptor availability, and compared these to non-transgenic rats. LRRK2 m...

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Literature Corpus work
69256fad-3574-5715-9042-afab1dc74367
DOI
10.1101/2023.08.09.550512
Open publication

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Dopamine D2 receptor upregulation in dorsal striatum in the <i>LRRK2</i> -R1441C rat model of early Parkinson’s disease revealed by <i>in vivo</i> PET imagingDOI 10.1101/2023.08.09.550512
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