Article

Pathogenic LRRK2 R1441C mutation is associated with striatal alterations

2020-03-12

Abstract excerpt

LRRK2 mutations are associated with both familial and sporadic forms of Parkinson’s disease (PD). Convergent evidence suggests that LRRK2 plays critical roles in regulating striatal function. Here, by using knock-in mouse lines that express the two most common LRRK2 pathogenic mutations—G2019S and R1441C—we investigated how pathogenic LRRK2 mutations altered striatal physiology. We found that R1441C mice displayed...

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Literature Corpus work: fba26a31-8f18-51ba-88ac-a9e5c1d188b4
DOI: 10.1101/2020.03.11.986455

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