Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake.

doi:10.7150/ijbs.7.753

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Article

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake.

International journal of biological sciences - 1 Jan 2011

Zhou Hongxia, Huang Cao, Tong Jianbin, Hong Weimin C, Liu Yong-Jian, Xia Xu-Gang

Abstract excerpt

Parkinson's disease (PD) results from progressive degeneration of dopaminergic neurons. Most PD cases are sporadic, but some have pathogenic mutation in the individual genes. Mutation of the leucine-rich repeat kinase-2 (LRRK2) gene is associated with familial and sporadic PD, as exemplified by G2019S substitution. While constitutive expression of mutant LRRK2 in transgenic mice fails to induce neuron death,...

Topics

Age Factors
Animals
Corpus Striatum
Disease Models, Animal
Dopamine
Dopamine Plasma Membrane Transport Proteins
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Locus Coeruleus
Microdialysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Motor Activity

Mutation

Parkinson Disease

Protein Serine-Threonine Kinases

Rats

Rats, Transgenic

Substantia Nigra

Source

Open in PubMed Open full text

Identifiers

PMID: 21698001
DOI: 10.7150/ijbs.7.753
PMCID: PMC3119847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21698001-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake.PMID 21698001Read ↗

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