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Article

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.

Acta neuropathologica communications - 14 Mar 2017

Longo Francesco, Mercatelli Daniela, Novello Salvatore, Arcuri Ludovico, Brugnoli Alberto, Vincenzi Fabrizio, Russo Isabella, Berti Giulia, Mabrouk Omar S, Kennedy Robert T, Shimshek Derya R, Varani Katia, Bubacco Luigi, Greggio Elisa, Morari Michele

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson's disease. Here, we investigated whether the G2019S LRRK2 mutation causes morphological and/or functional changes at nigro-striatal dopamine neurons. Density of striatal dopaminergic terminals, nigral cell counts, tyrosine hydroxylase protein levels as well as exocytotic dopamine release measured in striatal...

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Identifiers

PMID: 28292328
DOI: 10.1186/s40478-017-0426-8
PMCID: PMC5351259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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