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Article

Homozygous mutation of the LRRK2 ROC domain as a novel genetic model of parkinsonism.

Journal of biomedical science - 14 Aug 2022

Chen Meng-Ling, Wu Ruey-Meei

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is one of the most important neurodegenerative disorders in elderly people. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are found in a large proportion of the patients with sporadic and familial PD. Mutations can occur at different locations in the LRRK2. Patients with LRRK2 ROC-COR mutations face an increased risk of typical motor symptoms of PD, along with...

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Identifiers

PMID: 35965315
DOI: 10.1186/s12929-022-00844-9
PMCID: PMC9375908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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