Article
Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration.
Neurobiology of disease - 1 Nov 2014
Tsika Elpida, Kannan Meghna, Foo Caroline Shi-Yan, Dikeman Dustin, Glauser Liliane, Gellhaar Sandra, Galter Dagmar, Knott Graham W, Dawson Ted M, Dawson Valina L, Moore Darren J
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). The clinical and neurochemical features of LRRK2-linked PD are similar to idiopathic disease although neuropathology is somewhat heterogeneous. Dominant mutations in LRRK2 pre...
Topics
- Animals
- Arginine
- Cell Nucleolus
- Cells, Cultured
- Cysteine
- Dopaminergic Neurons
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mesencephalon
- Mice
- Mice, Transgenic
- Mutation
- Protein Serine-Threonine Kinases