Article
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Human molecular genetics - 1 Mar 2016
Sloan Max, Alegre-Abarrategui Javier, Potgieter Dawid, Kaufmann Anna-Kristin, Exley Richard, Deltheil Thierry, Threlfell Sarah, Connor-Robson Natalie, Brimblecombe Katherine, Wallings Rebecca, Cioroch Milena, Bannerman David M, Bolam J Paul, Magill Peter J, Cragg Stephanie J, Dodson Paul D, Wade-Martins Richard
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) lead to late-onset, autosomal dominant Parkinson's disease, characterized by the degeneration of dopamine neurons of the substantia nigra pars compacta, a deficit in dopamine neurotransmission and the development of motor and non-motor symptoms. The most prevalent Parkinson's disease LRRK2 mutations are located in the kinase (G2019S) and GTPase (R1441C) encoding...
Topics
- Action Potentials
- Aging
- Amino Acid Substitution
- Animals
- Antiparkinson Agents
- Cell Death
- Chromosomes, Artificial, Bacterial
- Corpus Striatum
- Disease Models, Animal