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Article

PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.

Brain : a journal of neurology - 1 Dec 2005

Adams John R, van Netten Hinke, Schulzer Michael, Mak Edwin, Mckenzie Jessamyn, Strongosky Audrey, Sossi Vesna, Ruth Thomas J, Lee Chong S, Farrer Matthew, Gasser Thomas, Uitti Ryan J, Calne Donald B, Wszolek Zbigniew K, Stoessl A Jon

Abstract excerpt

Parkinson's disease may arise from multiple aetiologies, including genetic mutations that are for the most part uncommon. We describe here the positron emission tomography (PET) findings in clinically affected and asymptomatic, high-risk members of two autosomal dominantly inherited Parkinson's disease kindreds with recently described mutations at the PARK8 locus, in a novel gene encoding a leucine-rich repeat...

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Identifiers

PMID: 16081470
DOI: 10.1093/brain/awh607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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