Article

Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons

2025-09-12

Abstract excerpt

<title>Abstract</title> <p>The end-stage pathology of Parkinson's disease (PD) involves the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). However, synaptic deregulation of these neurons begins much earlier. Understanding the mechanisms behind synaptic deficits is crucial for early therapeutic intervention, yet these remain largely unknown. In the SNc, different dopamine neuron su...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d508316-4aba-5a6e-bcd8-f941b25236e9
DOI: 10.21203/rs.3.rs-7518988/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axonsDOI 10.21203/rs.3.rs-7518988/v1Read

Leucine-rich repeat kinase 2 impairs the release sites of Parkinson’s disease vulnerable dopamine axonsSemantic proximity Read

LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights.Semantic proximity Read

RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursorsSemantic proximity Read

Pathway-specific deregulation of striatal excitatory synapses in LRRK2 mutationsSemantic proximity Read

Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis.Semantic proximity Read

LRRK2 pathobiology in Parkinson's disease.Semantic proximity Read

LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson's disease: a review.Semantic proximity Read

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synucleinSemantic proximity Read

Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutationsSemantic proximity Read

Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease.Semantic proximity Read

Exploring LRRK2-dependent Mechanisms in Parkinson's Disease Therapy.Semantic proximity Read

Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease: Updated from Pathogenesis to Potential Therapeutic TargetSemantic proximity Read