Article

An affinity-matured DLL4 ligand for broad-spectrum activation and inhibition of Notch signaling

2022-03-07

Abstract excerpt

<h4>ABSTRACT</h4> The Notch pathway regulates cell fate decisions and is an emerging target for regenerative and cancer therapies. Recombinant Notch ligands are attractive candidates for modulating Notch signaling; however, their intrinsically low receptor-binding affinity restricts their utility in biomedical applications. To overcome this limitation, we evolved variants of the ligand Delta-like 4 (DLL4) with en...

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Identifiers and source

Literature Corpus work: 6905d612-3c94-52e0-97b1-4f10be963052
DOI: 10.1101/2022.03.07.483330

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