Article

Single-chain nanobody inhibition of Notch and avidity enhancement utilizing the β-pore forming toxin Aerolysin

2024-10-25

Abstract excerpt

Notch plays critical roles in developmental processes and disease pathogenesis, which has led to numerous efforts to modulate its function with small molecules and antibodies. Here we present a nanobody inhibitor of Notch signaling, derived from a synthetic phage-display library targeting the notch Negative Regulatory Region (NRR). The nanobody inhibits Notch signaling in a luciferase reporter assay and in Notch-d...

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Identifiers and source

Literature Corpus work: 6a07eea6-b6ca-5eb8-81b5-5a4e134e18c5
DOI: 10.1101/2024.10.22.617501

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