Article

Delta C2 Domain β1-2 loop contributes to robust Notch signalling

2021-02-17

Abstract excerpt

<h4>Summary</h4> Accurate Notch signalling is critical for organism development and homeostasis. Fine-tuning of Notch-ligand interactions have substantial impact on signalling-outputs. Recent structural studies identified a conserved N-terminal C2 domain in human Notch ligands which conferred phospholipid binding in vitro. Here we show that Drosophila ligands adopt the same C2 domain structure with analogous vari...

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Literature Corpus work: f09b0042-348d-54da-b2fe-fce4f30ffa0e
DOI: 10.1101/2021.02.16.431397

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