Article
Notch-Jagged signaling complex defined by an interaction mosaic.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2021
Zeronian Matthieu R, Klykov Oleg, Portell I de Montserrat Júlia, Konijnenberg Maria J, Gaur Anamika, Scheltema Richard A, Janssen Bert J C
Abstract excerpt
The Notch signaling system links cellular fate to that of its neighbors, driving proliferation, apoptosis, and cell differentiation in metazoans, whereas dysfunction leads to debilitating developmental disorders and cancers. Other than a five-by-five domain complex, it is unclear how the 40 extracellular domains of the Notch1 receptor collectively engage the 19 domains of its canonical ligand, Jagged1, to...
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