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Article

Notch receptor-ligand binding and activation: insights from molecular studies.

Seminars in cell & developmental biology - 1 Jun 2012

Chillakuri Chandramouli R, Sheppard Devon, Lea Susan M, Handford Penny A

Abstract excerpt

The Notch receptor is part of a core signalling pathway which is highly conserved in all metazoan species. It is required for various cell fate decisions at multiple stages of development and in the adult organism, with dysregulation of the pathway associated with genetic and acquired diseases including cancer. Although cellular and in vivo studies have provided considerable insight into the downstream...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22326375
DOI: 10.1016/j.semcdb.2012.01.009
PMCID: PMC3415683

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