Article

Design of a Soluble Multivalent Notch Agonist

2024-08-08

Abstract excerpt

Designed protein agonists can enhance the efficiency of endogenous signaling pathways, and provide a powerful means to control cellular functions and develop disease therapeutics. Designing a soluble cytokine-like agonist for Notch signaling, an evolutionarily conserved pathway that regulates cell fate in embryonic and adult development, is especially challenging because Notch receptor activation requires a mechan...

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Literature Corpus work: 2ebf4fd4-5041-5107-b87d-12aef8721a17
DOI: 10.1101/2024.08.07.607099

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