Article

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

2017-01-18

Abstract excerpt

<h4>Abstract:</h4> Recent data have expanded our understanding of Notch signaling by identifying a C2 domain at the N-terminus of Notch ligands which has both lipid- and receptor-binding properties. We present novel structures of human ligands Jagged2 and DLL4 and human Notch-2, together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch binding is likely to be c...

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Literature Corpus work: e4600872-58e4-5b7f-ae64-88db6b6d7a4c
DOI: 10.1101/101394

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