Article
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.
PloS one - 8 Feb 2010
Aste-Amézaga Miguel, Zhang Ningyan, Lineberger Janet E, Arnold Beth A, Toner Timothy J, Gu Mingcheng, Huang Lingyi, Vitelli Salvatore, Vo Kim T, Haytko Peter, Zhao Jing Zhang, Baleydier Frederic, L'Heureux Sarah, Wang Hongfang, Gordon Wendy R, Thoryk Elizabeth, Andrawes Marie Blanke, Tiyanont Kittichoat, Stegmaier Kimberly, Roti Giovanni, Ross Kenneth N, Franlin Laura L, Wang Hui, Wang Fubao, Chastain Michael, Bett Andrew J, Audoly Laurent P, Aster Jon C, Blacklow Stephen C, Huber Hans E
Abstract excerpt
BACKGROUND: Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other hand, dysregulation of Notch1 signaling is associated with many different types of cancer as well as tumor angiogenesis, maki...
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