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Article

Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice.

eLife - 16 Jan 2020

Hirano Ken-Ichi, Suganami Akiko, Tamura Yutaka, Yagita Hideo, Habu Sonoko, Kitagawa Motoo, Sato Takehito, Hozumi Katsuto

Abstract excerpt

Delta-like (Dll) 1 and Dll4 differently function as Notch ligands in a context-dependent manner. As these ligands share structural properties, the molecular basis for their functional difference is poorly understood. Here, we investigated the superiority of Dll4 over Dll1 with respect to induction of T cell development using a domain-swapping approach in mice. The DOS motif, shared by Notch ligands-except...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31934853
DOI: 10.7554/eLife.50979
PMCID: PMC6986876

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Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice.PMID 31934853Read ↗

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