Article

The Spatio-Temporal Evolution of Multiple Myeloma from Baseline to Relapse-Refractory States

2022-01-21

Abstract excerpt

<title>Abstract</title> <p>Deciphering the evolution of tumor cells in the whole bone marrow (BM) cavity is key to inform curative strategies in multiple myeloma. Here, we performed spatial-longitudinal sequencing, including 144 samples collected from 25 patients during up to 14 years. Applying imaging-guided sampling we observed three evolution patterns, including relapse driven by a single tumor cell, competing...

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Literature Corpus work: 68e2b02f-972f-5db8-8d5c-5b5b33251416
DOI: 10.21203/rs.3.rs-1177985/v1

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