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The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous drug resistant disease

19 Mar 2024

Abstract excerpt

Multiple myeloma (MM) is an osteolytic malignancy that is incurable due to the emergence of treatment resistant disease. Defining how, when and where myeloma cell intrinsic and extrinsic bone microenvironmental mechanisms cause relapse is challenging with current biological approaches. Here, we report a biology-driven spatiotemporal hybrid agent-based model of the MM-bone microenvironment. Results indicate MM...

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PMID: 38503736
DOI: 10.1038/s41467-024-46594-0

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