Article

Deciphering spatial genomic heterogeneity at a single cell resolution in multiple myeloma

2021-01-16

Abstract excerpt

<title>Abstract</title> <p>Osteolytic lesions (OL) characterize symptomatic multiple myeloma. The mechanisms of how malignant plasma cells (PC) cause OL in one region while others show no signs of bone destruction despite subtotal infiltration remain unknown. We report the first single-cell RNA sequencing (scRNA-seq) study of PC obtained prospectively from random bone marrow aspirates (BM) and paired imaging-guid...

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Literature Corpus work: 0e6b10f0-cdf8-5126-abe7-6043d2d4f33e
DOI: 10.21203/rs.3.rs-146899/v1

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