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Article

A systematic literature review on clonal evolution events preceding relapse in multiple myeloma.

Critical reviews in oncology/hematology - 1 Jan 2025

Jakobsen Maja Zimmer, Brøndum Rasmus Froberg, Gregersen Henrik, Due Hanne, Dybkær Karen

Abstract excerpt

Despite considerable treatment advances, multiple myeloma (MM) remains an incurable hematological cancer due to treatment resistance. A systematic literature search was conducted to identify determinants for clonal evolution driving relapse and drug resistance in MM. A total of 631 non-duplicate publications were screened of which 28 articles were included for data extraction. Genetic alterations, mutational...

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PMID: 39549892
DOI: 10.1016/j.critrevonc.2024.104560

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