Article
Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing.
Nature communications - 16 Aug 2017
Rasche L, Chavan S S, Stephens O W, Patel P H, Tytarenko R, Ashby C, Bauer M, Stein C, Deshpande S, Wardell C, Buzder T, Molnar G, Zangari M, van Rhee F, Thanendrarajan S, Schinke C, Epstein J, Davies F E, Walker B A, Meissner T, Barlogie B, Morgan G J, Weinhold N
Abstract excerpt
In multiple myeloma malignant plasma cells expand within the bone marrow. Since this site is well-perfused, a rapid dissemination of "fitter" clones may be anticipated. However, an imbalanced distribution of multiple myeloma is frequently observed in medical imaging. Here, we perform multi-region sequencing, including iliac crest and radiology-guided focal lesion specimens from 51 patients to gain insight into...
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