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Article

The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states

3 Aug 2022

Abstract excerpt

Deciphering Multiple Myeloma evolution in the whole bone marrow is key to inform curative strategies. Here, we perform spatial-longitudinal whole-exome sequencing, including 140 samples collected from 24 Multiple Myeloma patients during up to 14 years. Applying imaging-guided sampling we observe three evolutionary patterns, including relapse driven by a single-cell expansion, competing/co-existing sub-clones, and...

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PMID: 35922426
DOI: 10.1038/s41467-022-32145-y

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