Article

Tumor suppressor heterozygosity and homologous recombination deficiency mediate resistance to front-line therapy in breast cancer

2024-02-08

Abstract excerpt

<h4>ABSTRACT</h4> The co-occurrence of germline and somatic oncogenic alterations is frequently observed in breast cancer, but their combined biologic and clinical significance has not been evaluated. To assess the role of germline-somatic interactions on outcomes in routine practice, we developed an integrated clinicogenomic pipeline to analyze the genomes of over 4,500 patients with breast cancer. We find that...

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Literature Corpus work: 30c690bc-2885-5023-a094-fb15b0dfb64a
DOI: 10.1101/2024.02.05.578934

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