Article

Optimized detection of allelic imbalances specific for homologous recombination deficiency improves the prediction of clinical outcomes in cancer

2021-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Homologous recombination DNA-repair deficiency (HRD) is a common driver of genomic instability and confers a therapeutic vulnerability in cancer. The accurate detection of somatic allelic imbalances (AIs) has been limited by methods focused on BRCA1/2 mutations and using mixtures of cancer types. Using pan-cancer data, we revealed distinct patterns of AIs in high-grade serous ovarian cancer (HG...

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Literature Corpus work: 594650f5-0f46-5390-a321-059b20a2718d
DOI: 10.1101/2021.08.19.456809

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