Article
The evolutionary history of 2,658 cancers
2017-07-11
Abstract excerpt
<h4>Summary</h4> Cancer develops through a process of somatic evolution. Here, we use whole-genome sequencing of 2,778 tumour samples from 2,658 donors to reconstruct the life history, evolution of mutational processes, and driver mutation sequences of 39 cancer types. The early phases of oncogenesis are driven by point mutations in a small set of driver genes, often including biallelic inactivation of tumour sup...
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Identifiers and source
- Literature Corpus work
- dcccb06d-1538-58a5-b67d-d3136c9a2d45
- DOI
- 10.1101/161562