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Article

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.

Science (New York, N.Y.) - 9 May 2014

Voss Felizia K, Ullrich Florian, Münch Jonas, Lazarow Katina, Lutter Darius, Mah Nancy, Andrade-Navarro Miguel A, von Kries Jens P, Stauber Tobias, Jentsch Thomas J

Abstract excerpt

Regulation of cell volume is critical for many cellular and organismal functions, yet the molecular identity of a key player, the volume-regulated anion channel VRAC, has remained unknown. A genome-wide small interfering RNA screen in mammalian cells identified LRRC8A as a VRAC component. LRRC8A formed heteromers with other LRRC8 multispan membrane proteins. Genomic disruption of LRRC8A ablated VRAC currents....

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PMID: 24790029
DOI: 10.1126/science.1252826

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