Article

Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex

2020-07-26

Abstract excerpt

Resting membrane potential determines the excitability of the cell and is essential for the cellular electrical activities. NALCN channel mediates sodium leak currents, which positively tune the resting membrane potential towards depolarization. NALCN channel is involved in many important neurological processes and is implicated in a spectrum of neurodevelopmental diseases. Despite its functional importance, the m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de3055c4-3e76-5f1b-96f1-dc089bee28cf
DOI: 10.1101/2020.07.26.221747

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complexDOI 10.1101/2020.07.26.221747Read

Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex.Semantic proximity Read

Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complexSemantic proximity Read

The sodium leak channel complex is modulated by voltage and extracellular calciumSemantic proximity Read

The Functional Properties, Physiological Roles, Channelopathy and Pharmacological Characteristics of the Slack (KCNT1) Channel.Semantic proximity Read

NALCN/Cch1 channelosome subunits originated in early eukaryotes and are fully conserved in animals, fungi, and apusomonadsSemantic proximity Read

To be or not to be an ion channel: cryo-EM structures have a saySemantic proximity Read

Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channelSemantic proximity Read

Gating in CNGA1 channels.Semantic proximity Read

Structural basis of human Nav1.5 gating mechanismsSemantic proximity Read

<i>De novo</i>variants of<i>NALCN</i>differentially impact both the phenotypic spectrum of patients and the biophysical properties of the NALCN currentSemantic proximity Read

Mapping Structural Distribution and Gating-Property Impacts of Disease-Associated Missense Mutations in Voltage-Gated Sodium ChannelsSemantic proximity Read

Structure of the human volume regulated anion channelSemantic proximity Read