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Article

The intracellular subdomain of the volume-regulated anion channel subunit LRRC8A is a hotspot of channel activation.

Nature communications - 17 Sept 2026

Bertelli Sara, Wang Lu, Klüssendorf Malte, Gavazzo Paola, Pusch Michael, Dutzler Raimund, Stauber Tobias

Abstract excerpt

Volume-regulated anion channels (VRACs), formed by heteromers of LRRC8 subunits, mediate the transport of anions and organic osmolytes in numerous physiological processes. Although their gating mechanism remains poorly understood, conformational rearrangements of the cytosolic leucine-rich repeat domains (LRRDs) have been implicated as a key step towards activation. Here, we identify the intracellular subdomain...

Read the complete abstract on PubMed

Topics

Membrane Proteins
Animals
Humans
Protein Domains
Ion Channel Gating
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cryoelectron Microscopy

Tryptophan

HEK293 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 42754616
DOI: 10.1038/s41467-026-77507-y
PMCID: PMC13586329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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