Article

Structural insights into ion conduction by novel cation channel, TMEM87A, in Golgi apparatus

2023-01-03

Abstract excerpt

TMEM87 family is evolutionarily conserved eukaryotic transmembrane proteins residing in the Golgi 1 . TMEM87 members play a role in retrograde transport in Golgi and are also proposed mechanosensitive ion channel implicated in cancer and heart disease 2–7 . In an accompanying study, TMEM87A is described as a voltage-gated, pH-sensitive, non-selective cation channel whose genetic ablation in mice disrupts Golgi m...

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Literature Corpus work: f5ceddde-8384-5666-92fc-84df7ff9ef81
DOI: 10.1101/2023.01.03.522544

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