Article

Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity

2018-05-22

Abstract excerpt

<h4>Background</h4> Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases the effective number of functionally distinct gene products. Using bulk RNA sequencing, splicing variation has been studied across human tissues and in genetically diverse populations. This has identified disease-relevant splicing events, as well as associations between splicing and genomic variations, includi...

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Literature Corpus work: 68638364-778e-576b-8559-e281c0700a37
DOI: 10.1101/328138

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