Article
Tissue-specific effects of genetic and epigenetic variation on gene regulation and splicing.
PLoS genetics - 1 Jan 2015
Gutierrez-Arcelus Maria, Ongen Halit, Lappalainen Tuuli, Montgomery Stephen B, Buil Alfonso, Yurovsky Alisa, Bryois Julien, Padioleau Ismael, Romano Luciana, Planchon Alexandra, Falconnet Emilie, Bielser Deborah, Gagnebin Maryline, Giger Thomas, Borel Christelle, Letourneau Audrey, Makrythanasis Periklis, Guipponi Michel, Gehrig Corinne, Antonarakis Stylianos E, Dermitzakis Emmanouil T
Abstract excerpt
Understanding how genetic variation affects distinct cellular phenotypes, such as gene expression levels, alternative splicing and DNA methylation levels, is essential for better understanding of complex diseases and traits. Furthermore, how inter-individual variation of DNA methylation is associ...
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