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Article

Additional Sex Combs-like Family Associated with Epigenetic Regulation.

International journal of molecular sciences - 8 May 2024

Kim Nackhyoung, Byun Sukyoung, Um Soo-Jong

Abstract excerpt

The additional sex combs-like (ASXL) family, a mammalian homolog of the additional sex combs (Asx) of Drosophila, has been implicated in transcriptional regulation via chromatin modifications. Abnormal expression of ASXL family genes leads to myelodysplastic syndromes and various types of leukemia. De novo mutation of these genes also causes developmental disorders. Genes in this family and their neighbor genes...

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Identifiers

PMID: 38791157
DOI: 10.3390/ijms25105119
PMCID: PMC11121404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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