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Article

Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.

Developmental biology - 1 Jan 2010

Fisher C L, Lee I, Bloyer S, Bozza S, Chevalier J, Dahl A, Bodner C, Helgason C D, Hess J L, Humphries R K, Brock H W

Abstract excerpt

The Additional sex combs (Asx) gene of Drosophila behaves genetically as an enhancer of trithorax and polycomb (ETP) in displaying bidirectional homeotic phenotypes, suggesting that is required for maintenance of both activation and silencing of Hox genes. There are three murine homologs of Asx called Additional sex combs-like1, 2, and 3. Asxl1 is required for normal adult hematopoiesis; however, its embryonic...

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Identifiers

PMID: 19833123
DOI: 10.1016/j.ydbio.2009.10.004
PMCID: PMC2807749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.PMID 19833123Read ↗

The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs.Semantic proximity Read ↗

Additional Sex Combs-Like Family Associated with Epigenetic RegulationSemantic proximity Read ↗

The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.Semantic proximity Read ↗

Additional Sex Combs-like Family Associated with Epigenetic Regulation.Semantic proximity Read ↗

Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia.Semantic proximity Read ↗

Genetic analysis of the additional sex combs locus of Drosophila melanogaster.Semantic proximity Read ↗

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Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.Semantic proximity Read ↗

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