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Article

SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis

28 Nov 2023

Abstract excerpt

Additional sex combs-like 1 (ASXL1) gene is highly mutated in a spectrum of myeloid malignancies, including ~49% of chronic myelomonocytic leukemia (CMML) [ 1 ], ~10% of acute myeloid leukemia (AML) [ 2 ], ~21% of myelodysplastic syndromes (MDS) [ 3 ], ~10% of myeloproliferative neoplasms (MPN) [ 4 ], and ~8% of juvenile myelomonocytic leukemia (JMML) [ 5 ]. The majority of ASXL1- mutated patients had other...

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PMID: 38017104
DOI: 10.1038/s41375-023-02094-6

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