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Article

SLOAD: a comprehensive database of cancer-specific synthetic lethal interactions for precision cancer therapy via multi-omics analysis.

Database : the journal of biological databases and curation - 27 Aug 2022

Guo Li, Dou Yuyang, Xia Daoliang, Yin Zibo, Xiang Yangyang, Luo Lulu, Zhang Yuting, Wang Jun, Liang Tingming

Abstract excerpt

Synthetic lethality has been widely concerned because of its potential role in cancer treatment, which can be harnessed to selectively kill cancer cells via identifying inactive genes in a specific cancer type and further targeting the corresponding synthetic lethal partners. Herein, to obtain cancer-specific synthetic lethal interactions, we aimed to predict genetic interactions via a pan-cancer analysis from...

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PMID: 36029479
DOI: 10.1093/database/baac075
PMCID: PMC9419874

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