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Article

Pathway-driven analysis of synthetic lethal interactions in cancer using perturbation screens.

Life science alliance - 1 Jan 2024

Karimpour Mina, Totonchi Mehdi, Behmanesh Mehrdad, Montazeri Hesam

Abstract excerpt

Synthetic lethality offers a promising approach for developing effective therapeutic interventions in cancer when direct targeting of driver genes is impractical. In this study, we comprehensively analyzed large-scale CRISPR, shRNA, and PRISM screens to identify potential synthetic lethal (SL) interactions in pan-cancer and 12 individual cancer types, using a new computational framework that leverages the...

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Identifiers

PMID: 37863651
DOI: 10.26508/lsa.202302268
PMCID: PMC10589366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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