Article

Using graph-based model to identify cell specific synthetic lethal effects

2023-07-25

Abstract excerpt

<h4>ABSTRACT</h4> Synthetic lethal (SL) pairs are pairs of genes whose simultaneous loss-of-function results in cell death, while a damaging mutation of either gene alone does not affect the cell’s survival. This makes SL pairs attractive targets for precision cancer therapies, as targeting the unimpaired gene of the SL pair can selectively kill cancer cells that already harbor the impaired gene. Limited by the d...

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Literature Corpus work: 4a6bebe7-1927-5c89-94d8-22f3de15b4c8
DOI: 10.1101/2023.07.23.550246

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