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Article

Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer.

Cancer gene therapy - 1 Feb 2024

Geng Haigang, Qian Ruolan, Zhong Yiqing, Tang Xiangyu, Zhang Xiaojun, Zhang Linmeng, Yang Chen, Li Tingting, Dong Zhongyi, Wang Cun, Zhang Zizhen, Zhu Chunchao

Abstract excerpt

Since trastuzumab was approved in 2012 for the first-line treatment of gastric cancer (GC), no significant advancement in GC targeted therapies has occurred. Synthetic lethality refers to the concept that simultaneous dysfunction of a pair of genes results in a lethal effect on cells, while the loss of an individual gene does not cause this effect. Through exploiting synthetic lethality, novel targeted therapies...

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PMID: 38040871
DOI: 10.1038/s41417-023-00706-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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