Article
Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer.
Biology direct - 1 Oct 2015
Srihari Sriganesh, Singla Jitin, Wong Limsoon, Ragan Mark A
Abstract excerpt
BACKGROUND: Synthetic lethality (SL) refers to the genetic interaction between two or more genes where only their co-alteration (e.g. by mutations, amplifications or deletions) results in cell death. In recent years, SL has emerged as an attractive therapeutic strategy against cancer: by targeting the SL partners of altered genes in cancer cells, these cells can be selectively killed while sparing the normal...
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