Article

SLAYER: A Computational Framework for Identifying Synthetic Lethal Interactions through Integrated Analysis of Cancer Dependencies

2024-05-04

Abstract excerpt

Synthetic lethality represents a promising therapeutic approach in precision oncology, yet systematic identification of clinically relevant synthetic lethal interactions remains challenging. Here we present SLAYER (Synthetic Lethality AnalYsis for Enhanced taRgeted therapy), a computational framework that integrates cancer genomic data and genome-wide CRISPR knockout screens to identify potential synthetic lethal...

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Literature Corpus work: 5da8c58e-a9d2-5489-8ed1-70f78cc436b5
DOI: 10.1101/2024.05.01.592073

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