Article
Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.
Cancer discovery - 1 Feb 2015
Martins Maria M, Zhou Alicia Y, Corella Alexandra, Horiuchi Dai, Yau Christina, Rakhshandehroo Taha, Gordan John D, Levin Rebecca S, Johnson Jeff, Jascur John, Shales Mike, Sorrentino Antonio, Cheah Jaime, Clemons Paul A, Shamji Alykhan F, Schreiber Stuart L, Krogan Nevan J, Shokat Kevan M, McCormick Frank, Goga Andrei, Bandyopadhyay Sourav
Abstract excerpt
UNLABELLED: There is an urgent need in oncology to link molecular aberrations in tumors with therapeutics that can be administered in a personalized fashion. One approach identifies synthetic-lethal genetic interactions or dependencies that cancer cells acquire in the presence of specific mutations. Using engineered isogenic cells, we generated a systematic and quantitative chemical-genetic interaction map that...
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