Article

Structural framework for the assembly of the human tRNA ligase complex

2025-08-02

Abstract excerpt

In human cells, a subset of tRNA-encoding genes contain introns. These are removed by a non-canonical splicing pathway in which the tRNA splicing endonuclease complex catalyzes intron excision and the resulting exons are subsequently ligated by the tRNA-ligase complex (tRNA-LC). Although recent studies have provided insights into the process of intron removal, the molecular mechanisms underpinning tRNA ligation by...

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Literature Corpus work: efe4a9dd-3262-5237-b058-676bc271b206
DOI: 10.1101/2025.08.01.668197

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