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Article

Challenges and Opportunities for Developing More Generalizable Polygenic Risk Scores.

Annual review of biomedical data science - 10 Aug 2022

Wang Ying, Tsuo Kristin, Kanai Masahiro, Neale Benjamin M, Martin Alicia R

Abstract excerpt

Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and diseases by aggregating information across multiple genetic variants identified from genome-wide association studies. PRS can predict a broad spectrum of diseases and have therefore been widely used in research settings. Some work has investigated their potential applications as biomarkers in preventative medicine, but...

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PMID: 35576555
DOI: 10.1146/annurev-biodatasci-111721-074830
PMCID: PMC9828290

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