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Article

Genetic prediction of complex traits with polygenic scores: a statistical review.

Trends in genetics : TIG - 1 Nov 2021

Ma Ying, Zhou Xiang

Abstract excerpt

Accurate genetic prediction of complex traits can facilitate disease screening, improve early intervention, and aid in the development of personalized medicine. Genetic prediction of complex traits requires the development of statistical methods that can properly model polygenic architecture and construct a polygenic score (PGS). We present a comprehensive review of 46 methods for PGS construction. We connect the...

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Identifiers

PMID: 34243982
DOI: 10.1016/j.tig.2021.06.004
PMCID: PMC8511058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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